Comparative single cell analyses of principal neurons and Interneurons in mice and humans

End date 2017-09-30 17:00:00 (GMT+1)

The Human Brain Project

The Human Brain Project (HBP, is an ambitious 10-year research initiative, and part of the EU flagship program[1]. HBP is developing an innovative ICT infrastructure (the HBP Joint Platform), that will help neuroscientists and clinical researchers integrate data and knowledge about the brain across all levels of its spatial and temporal organisation. Using detailed digital representations, reconstructions, and simulations it aims to give tools to thousands of researchers to advance and accelerate our understanding of the functioning of the human brain and its diseases.

Through this Call for Expressions of Interest (CEoI), HBP is looking for new Partners with a strong track record in comparative single cell analyses of principal neurons and Interneurons in mice and human, to join the project's next phase, which will be funded under Horizon 2020 (H2020).

Scope of the Call for Comparative single cell analyses of principal neurons and Interneurons in mice and humans

Under this CEoI, potential new Partners are encouraged to group up with other prospective Partners and existing HBP PIs of their choice, and together submit a proposal for a challenging project addressing comparative single cell analyses of principal neurons and Interneurons in mice and human.

The human brain is extremely challenging — not only because of its complexity and the technical difficulties involved, but also because ethical limitations do not allow all of the necessary datasets to be acquired directly from human brains. But the human brain shares many common features with other non-human mammals that might be considered as basic bricks of brain organisation and which, by definition, are common to all mammalian species. For this general purpose, many neuroscientists suggest that the ideal experimental animals at present are rodents because they can be manipulated to study many aspects, from genes to behaviour. Furthermore, we can use relatively large numbers of animals at a relatively low cost. Therefore, choosing appropriate experiments to obtain strategic data that could be extrapolated to the human brain will be a major goal.

One proposal will be selected, becoming Tasks 1.5.7 and 2.5.9 in the HBP Work Plan for the SGA2 period (1 April 2018 to 31 March 2020), housed within the HBP’s Subproject 1[2] and Subproject 2.

The selected new Partner Organisation(s)[3] will be incorporated in the HBP Consortium. The new Partners will be requested to sign the relevant agreements with the European Commission (EC) as well as the Consortium Agreement that regulates the relations between the Partners of the Consortium.

The agreements with the EC include a Framework Partnership Agreement (FPA[4]) and a Specific Grant Agreement (SGA). The FPA-Consortium Agreement applies to all SGAs under the FPA. The addition of new Partners to the Consortium is subject to the approval of the required FPA amendment by the HBP Stakeholder Board and the European Commission.

Success in this Call should not be considered as a commitment by the HBP or the EC to continue funding the Partners after the end of the SGA2 period. The continuation of this activity will be subject to the same review as all other HBP activities.




[3] Partner = an organization, not an individual


Financial information: H2020 Annotated Grant Agreement
HBP_SGA2_Joint Platform
HBP definitions
HBP_FPA extract for SP Objectives in SGA2
HBP_SP&CDP Contact information
Guidelines Open Call Management Platform
HBP_Call_Text_CEoI_Comparative single cell analyses
HBP_CEoI_Guide for Applicants_on_Comparative single cell analyses
HBP_CEoI_Proposal Template_for_Comparative single cell analyses